The HIV genotypic drug resistance algorithm within SmartGene for Stanford HIVDB has been updated.
As you are likely aware, HIVDB version 9.2 (October 2022) added the gag-p24 target to the Stanford algorithm and the Capsid Inhibitor drug class (CAI), including the drug Lenacapavir (LEN).
HIVDB version 9.4 (December 2022) added comments regarding Capsid Inhibitor (CAI) mutations without any score change. At this time, Version 9.4 does not yet display an interpretation score for CAI which may lead to potential discrepancies for that drug class compared to other drug resistance interpretation algorithms.
Please note: HIVDB version 9.3 (November 2022) included score updates for NRTI drugs ABC, AZT, TDF, and 3TC/FTC.
The online reference and details about Stanford's HIVdb algorithm updates can be found here.