Prevalence of doravirine-associated resistance mutations in HIV-1-infected antiretroviral-experienced patients from two large databases in France and Italy

C. Soulie, MM Santoro, A. Storto, B. Abdi, C. Charpentier, D. Armenia, A. Jary, F. Forbici, A. Bertoli, W. Gennari, M. Andreoni, C. Mussini, A. Antinori, CF Perno, V. Calvez, F. Ceccherini-Silberstein, D. Descamps, and AG Marcelin. Journal of Antimicrobial Chemotherapy, 2020 Apr 1;75(4):1026-1030. doi: 10.1093/jac/dkz553. This email address is being protected from spambots. You need JavaScript enabled to view it.

Citation: "... Doravirine-associated resistance mutations identified in vitro or in vivo were studied in a set of 9199 HIV-1 RT sequences from HIV-1 antiretroviral-experienced patients, including 381 NNRTI-failing patients in France and Italy between 2012 and 2017. ... Resistance interpretation was made using the Smartgene® Integrated Database Network System (SmartGene, Switzerland; according to the Stanford and ANRS algorithms. Resistance and possible resistance were grouped as resistance. ... Subtype was determined on the basis of the RT and protease coding regions by the SmartGene algorithmor by phylogenetic analyses, using reference sequences of HIV-1 subtypes and circulating recombinant forms (CRFs) from the Los Alamos Database ..."